Rheumatoid artritis

by Josh

Rheumatoid artritis

Some have criticized me for coining the terms Rheumatoid Disease and rheumatoid heart disease , but I can’t really take credit for them. I’ve just read lots of medical history in the past few years. The historical, and medically correct, term “Rheumatoid Disease” and its abbreviation “RD” are used today by clinicians and researchers, especially outside of rheumatology. If you were a pulmonologist studying the effect of RD on the lungs, you would feel silly talking about “arthritis” because you know there are no joints in the lungs. The same goes for eyes, heart, or vocal cords.

Starting with studies in mice, the researchers found that animals that ate a diet high in the sulforaphane found in broccoli had significantly less cartilage damage and signs of osteoarthritis compared to mice who did not consume sulforaphane. The team then moved to human and cow cartilage cells, and found that the sulforaphane was equally effective in protecting these cells from damage. The sulfur-based compound, they say, may be blocking enzymes that contribute to inflammation in cartilage, and the scientists are starting a trial to see if broccoli can protect a small group of arthritis patients getting knee replacement surgery.Arthritis


Treatment with Cimzia should not be initiated in patients with an active infection, including clinically important localized infections. Cimzia should be discontinued if a patient develops a serious infection or sepsis. Patients greater than 65 years of age, patients with co-morbid conditions, and/or patients taking concomitant immunosuppressants (e.g. corticosteroids or methotrexate) may be at a greater risk of infection. Patients who develop a new infection during treatment with CIMZIA® should be closely monitored, undergo a prompt and complete diagnostic workup appropriate for immunocompromised patients, and appropriate antimicrobial therapy should be initiated.

Although there has been a lack of systematic research (in western countries), a case study published in The Lancet found that daily doses of 6 to 9 mg per day were sufficient to cause arthritis in an avid tea-drinker (Cook 1971). The subject of the study , an English woman with a 25-year history of debilitating arthritis, experienced complete relief in her symptoms within 6 months of stopping her tea consumption. In light of the woman’s recovery, the author concluded that “some cases of pain diagnosed as rheumatism or arthritis may be due to subclinical fluorosis which is not radiologically demonstrable.”

The Phase II pratfall closely follows a hit for the company's diabetes drug APOCIIIRx. Just weeks ago Isis reported that after 13 weeks of weekly injections of ISIS-APOCIIIRx-designed to hit the "off" switch on a gene that produces the apolipoprotein C-III protein, involved in triglyceride regulation-there was a 72% plunge in fatty particles and a 40% spike in HDL, or good cholesterol, along with improved insulin sensitivity among the 11 patients with Type 2 diabetes in the study. And near the start of this year Isis and its partner Genzyme won an approval for Kynamro for rare cases of homozygous familial hypercholesterolemia.

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